MFN2-a multifaceted guardian against Parkinson's pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide and its exact pathogenesis remains unclear. This study aims to comprehensively explore the role of MFN2 in PD based on in vivo and in vitro models for multidimensional understanding.

Methods

In vivo, C57BL/6 J male mice were administered MPTP and probenecid by intraperitoneal injection to establish PD models. Lentivirus carrying MFN2 was microinjected into the bilateral striatum of specific groups of mice. The motor and cognitive functions of the mice were evaluated using the rotarod test and the open field test. In vitro, SH-SY5Y cells were treated with MPP⁺ to establish cell-based PD models. Transfection of plasmids was used to achieve

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC12479552 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature