Prognostic value of whole-body diffusion-weighted imaging with background body signal suppression in CRPC patients undergoing Ra-223 therapy: an exploratory analysis.

ABSTRACT:

Objectives

The aim of this study was to evaluate the utility of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in monitoring the response to Ra-223 therapy in patients with castration-resistant prostate cancer (CRPC) and bone metastasis.

Materials and methods

This retrospective study included 15 patients with CRPC and bone metastases. DWIBS scans were performed at baseline and after three cycles of Ra-223 therapy. Quantitative analysis of tumor total diffusion volume (tDV) categorized patients as stable disease (DWIBS-SD), partial response (DWIBS-PR), or progressive disease (DWIBS-PD). Kaplan-Meier analysis and log-rank tests were used to assess the correlation between DWIBS findings and survival.

Results

Of the 15 patients (medi

SUBMITTER: Kono Y 

PROVIDER: S-EPMC12479555 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature