[Tuberculosis Risk and Efficacy of Latent Tuberculosis Infection Treatment among Participants of National Latent Tuberculosis Infection Screening Program].

ABSTRACT: The study aim was to investigate the natural history of latent tuberculosis infection (LTBI) and the efficacy of LTBI treatment among participants in the national LTBI screening program. Individuals who underwent an interferon-gamma release assay (IGRA) between 2017 and 2020 were included, and tuberculosis (TB) development was investigated until April 2021. Cox proportional hazards models were used to investigate the risk factors affecting TB incidence among IGRA-negative and IGRA-positive individuals who did not undergo treatment. Additionally, the numbers needed to treat (NNT), stratified by age and interferon levels, were calculated among IGRA-positive individuals who did not undergo treatment and those who completed treatment. A comparison with contacts enrolled within the same period

SUBMITTER: Kim HW 

PROVIDER: S-EPMC12479656 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature