High visceral-to-subcutaneous fat area ratio is an unfavorable prognostic indicator in patients with uterine sarcoma.

ABSTRACT:

Purpose

Uterine sarcoma is a rare disease whose association with body composition parameters is poorly understood. This study explored the impact of body composition parameters on overall survival with uterine sarcoma.

Materials and methods

This multicenter study included 52 patients with uterine sarcomas treated at three Japanese hospitals between 2007 and 2023. A semi-automatic segmentation program based on deep learning analyzed transaxial CT images at the L3 vertebral level, calculating body composition parameters as follows: area indices (areas divided by height squared) of skeletal muscle, visceral and subcutaneous adipose tissue (SMI, VATI, and SATI, respectively); skeletal muscle density; and the visceral-to-subcutaneous fat area ratio (VSR). The optimal cutoff value

SUBMITTER: Kurokawa M 

PROVIDER: S-EPMC12479680 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature