Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus.

ABSTRACT: People with type 1 or type 2 diabetes mellitus (T1DM or T2DM) often experience cognitive impairment. We profiled cells in the nucleus basalis of Meynert (NBM) in postmortem human brain tissue to investigate the neuropathological changes. Sixty-eight postmortem NBM samples were grouped as T1DM, T2DM, and controls without diabetes, with Braak stage 0-II or III-VI. T1DM subjects had only Braak stage 0-II and were thus compared only to controls with a similar Braak stage and not subjects with Braak stage III-VI. We analyzed neurons expressing choline acetyltransferase (ChAT), phosphorylated tau, amyloid-beta, glial cells, and vasculature with their respective markers. We found significantly lower neuronal expression of ChAT in T1DM individuals than in controls and T2DM individuals with Braak s

SUBMITTER: Jiang W 

PROVIDER: S-EPMC12479689 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature