Effects of NSAIDs on Early CKD Development: A 10-Year Population-Based Study Using the Korean Senior Cohort.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management but are associated with nephrotoxicity, particularly in senior populations. While the acute nephrotoxicity of NSAIDs is well established, evidence on their long-term effects on renal function-particularly in community-dwelling older adults-has been mixed across studies.

Objectives

This study investigated the association between NSAID use and chronic kidney disease (CKD) risk in the general senior population.

Methods

Data from the National Health Insurance Service-Senior Cohort (NHIS-SC) in South Korea were analyzed, including 1812 participants (604 NSAID users and 1208 controls) matched 1:2 by propensity score. Kidney dysfunction was defined as glomerular filtration rate (eGFR

SUBMITTER: Lim JS 

PROVIDER: S-EPMC12479701 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature