A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut.

ABSTRACT: Metabolism and gut microbiota are essential for newborn health, influencing immune function, energy balance, and growth. Breast milk provides IgA, crucial for shaping gut microbiota in infants. In non-breastfed newborns, we observe the presence of IgM antibodies that can recognize various bacteria, influence bacterial clustering, and alter bacterial metabolism, such as carbon source utilization in vitro within small bacterial communities. Based on these findings, we developed a monoclonal IgM, M291, derived from a newborn-B cell, which mimics naturally occurring antibodies and could serve as a surrogate tool to modulate intestinal bacterial functions and metabolism. Oral administration of M291 alters the metabolome of germ-free mice colonized with a defined bacterial consortium or an infan

SUBMITTER: He Z 

PROVIDER: S-EPMC12479768 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature