Elucidating the role of group A Streptococcus genomics and pharyngeal microbiota in acute paediatric pharyngitis.

ABSTRACT: The post pandemic period has witnessed a notable increase in invasive Streptococcus pyogenes (GAS) infections across several countries. This surge has been partly attributed to the emergence of more virulent strains, and factors like the non-pharmaceutical interventions or the immunity debt. Despite its dual role as both a commensal and pathogen, our understanding of GAS carriage and the dynamics influencing the transition to invasive disease remains limited. In particular, the role of the pharyngeal microbiota in modulating GAS colonization and infection warrants further investigation. We performed a comprehensive analysis of a pediatric cohort in the post pandemic period collecting clinical data alongside diagnostic evaluations by using pharyngeal swabs and Rapid Antigen Detection Tests

SUBMITTER: De Maio F 

PROVIDER: S-EPMC12479793 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature