Characterization of brain microstructural abnormalities in spasmodic dysphonia using diffusion kurtosis imaging.

ABSTRACT: To investigate microstructural changes in spasmodic dysphonia (SD) patients applying diffusion kurtosis imaging (DKI) data. DKI (b-values = 0, 1,000, and 2,000 s/mm²) was performed for 20 SD patients and 20 controls. DKI parameters including kurtosis fractional anisotropy (FA), mean diffusion (MD), and mean kurtosis (MK). The correlation analysis was used to assess the correlation between changes in FA and clinical measures. Compared to healthy controls, SD patients showed significantly reduced FA and increased MD in the white matter (WM) and gray matter (GM). Increases of MK had broader distributions than MD. In the WM, the FA and MD of frontal and jitter values had significant inverse correlations in SD patients. The FA and MD were negative correlated with grade, and the FA in

SUBMITTER: Jiang F 

PROVIDER: S-EPMC12479905 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature