Randomised phase-2 screening trial of intermittent energy restriction plus resistance exercise versus resistance exercise alone during chemotherapy for advanced breast cancer.

ABSTRACT:

Background

Weight control and energy restriction could improve survival in patients with advanced breast cancer (ABC) but randomised data are lacking. A randomised screening trial was conducted to assess an intermittent energy restricted diet and resistance exercise intervention (IER + RE) vs RE alone (RE) on progression free survival (PFS), toxicity and Quality of Life (QoL) during chemotherapy for ABC.

Methods

Sixty-eight women were randomised to IER + RE (n = 35) or RE (n = 33) with one-sided significance assessed at the 20% threshold. The primary end point was PFS secondary endpoints included chemotherapy toxicity, weight change and QoL.

Results

The adjusted hazard rate for progression comparing IER + RE vs RE was 0.729 (0.391-1.361) and the median PFS 42.0 vs 26.

SUBMITTER: Harvie M 

PROVIDER: S-EPMC12479916 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature