T817MA protects against inflammation and pyroptosis in response to brain ischemia via activating Sirt1 signaling.

ABSTRACT: Ischemic stroke remains a leading cause of death and disability worldwide, yet effective neuroprotective therapies are lacking. Neuroinflammation and pyroptosis, a lytic and inflammatory form of programmed cell death, exacerbate secondary brain injury post-ischemia. This study investigated the neuroprotective effects of T817MA, a neurotrophic agent, in a rat model of transient middle cerebral artery occlusion (MCAO), focusing on its anti-pyroptotic mechanisms via Sirtuin1 (Sirt1) signaling. Animals were pretreated orally with T817MA at 30 mg/kg for 20 days, and brain edema was evaluated by brain water content. Neurological dysfunction was determined by modified neurological severity score (mNSS) and rotating pole test, and neuroinflammatory markers were assayed by immunostaining. Pyroptosi

SUBMITTER: Wang T 

PROVIDER: S-EPMC12480052 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature