MIEN1 promoter deletion leads to impaired migration and invasion potential via actin cytoskeleton rearrangement in colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Although early-stage CRC is responsive to surgical resection, advanced metastatic disease poses formidable treatment obstacles, triggering an alarming decline in the survival rates of patients. Hence, studying the mechanisms underlying CRC progression and identifying novel therapeutic targets are critical for early diagnosis and treatment. The migration and invasion enhancer 1 (MIEN1) protein plays a pivotal role in tumor invasion and migration across various cancer types. In CRC, the predominant upregulation of MIEN1 in cancerous tissues is closely associated with invasive behavior; however, the precise mechanism driving the metastasis remains unexplored. In this study, we investigate the role of MIEN1 in

SUBMITTER: Ranade P 

PROVIDER: S-EPMC12480079 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature