Differentiation of acute-phase AQP4-IgG+ optic neuritis from CNS inflammatory diseases using optic nerve head blood flow analysis.

ABSTRACT: Early diagnosis of optic neuritis (ON) associated with aquaporin-4 immunoglobulin-G (AQP4-IgG), myelin oligodendrocyte glycoprotein immunoglobulin-G (MOG-IgG), or multiple sclerosis (MS) is challenging due to invasive and time-consuming tests. We investigated whether ophthalmologic assessments, including laser speckle flowgraphy (LSFG) and optical coherence tomography (OCT), are useful for distinguishing among these diseases at ON onset. This retrospective study included 10 AQP4-IgG+ON patients, 20 MOG-IgG+ON patients, 9 MS-ON patients, and 27 idiopathic ON (ION) patients at initial onset, and 66 propensity-score-matched control eyes. We measured mean blur rate (MBR), representing blood flow velocity, using LSFG and assessed optic nerve head (ONH) vessel-area MBR (ONH-MV), tissue-area MBR

SUBMITTER: Yamaguchi C 

PROVIDER: S-EPMC12480100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature