Sexual dimorphism in zebrafish liver proteins and implications for hepatic regeneration and diseases.

ABSTRACT: The liver is a central metabolic hub, performing vital functions such as bile production, protein, carbohydrate, lipid and drug metabolism, detoxification of xenobiotics, and the synthesis of essential biomolecules for reproduction, and also shows regenerative capability. Several of these functions can be affected by sexual dimorphisms with important consequences. In this study we used high-throughput proteomics to identify and quantify proteins involved in sexual dimorphism of the zebrafish liver, as a model for preclinical human research. Additionally, we conducted an extensive literature review to explore potential effects of sex-biased protein abundances on liver regeneration capacity and hepatic diseases. The results showed wide-spread sex-specific differences in proteins involved in

SUBMITTER: Niksirat H 

PROVIDER: S-EPMC12480104 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature