Circulating biomarkers of vasoplegia: a systematic review.

ABSTRACT:

Background

Vasoplegia is characterised by persistent hypotension and reduced systemic vascular resistance despite preserved cardiac output, commonly arising in sepsis, following major surgery, and within systemic inflammatory responses. Despite its clinical significance and association with poor outcomes, there is no universally accepted definition or standardised biomarker, impeding early diagnosis, stratification, and targeted therapy. While individual studies have examined biomarkers within specific clinical contexts such as septic shock or cardiac surgery, no comprehensive synthesis across all aetiologies of vasoplegia has previously been undertaken.

Objectives

To systematically evaluate and synthesise the current evidence regarding circulating biomarkers associated with

SUBMITTER: Boyer N 

PROVIDER: S-EPMC12480150 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature