Pharmacological inhibition of NMDA receptors reduces migration and viability in triple-negative inflammatory breast cancer cell lines.

ABSTRACT:

Purpose

NMDA receptors (NMDARs), best known for their role in neuronal signaling, have been linked to breast cancer progression and metastasis, but their involvement in Inflammatory Breast Cancer (IBC) remains unexplored. IBC is a rare, invasive subtype with rapid progression, poor prognosis, and a high propensity for brain metastasis. Given the neuronal functions of NMDARs and IBC's high brain metastasis rates, we hypothesized that MNDARs may contribute to IBC's aggressive phenotype and represent a novel therapeutic target.

Methods

IBC cell lines (SUM149PT and SUM190PT) and non-IBC controls (MBA-MB-231 and MCF7) were cultured in 2D and 3D systems to assess NMDAR mRNA and protein expression. Immunochemistry followed by confocal microscopy was performed to localize NMDARs wit

SUBMITTER: Mendez-Santacruz LL 

PROVIDER: S-EPMC12480174 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature