Epidemiology and Course of Clostridioides difficile Infections in Germany: Retrospective Analysis of German Health Claims Data.

ABSTRACT:

Introduction

Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated infectious diarrhea, with recurrence rates of 15-20% after standard treatment and ≥ 30% after a second relapse. In Germany, reliable epidemiological data remain limited.

Methods

A retrospective claims data analysis of the period 2017-2022 was performed using the German Analysis Database for Evaluation and Health Services Research (DADB), which covers 4.1 million insured individuals. Incident CDI cases, recurrent cases, and mortality were assessed and stratified by diagnosis setting. A propensity-score-matched control group without CDI adjusted for age, sex, and comorbidities was created. Cox proportional hazards models were used to determine mortality risk factors.

Results<

SUBMITTER: Seiffert A 

PROVIDER: S-EPMC12480187 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature