Global research trends in CAR-T cell therapy for glioblastoma: a bibliometric and visualized analysis.

ABSTRACT:

Background

Glioblastoma (GBM) is the most aggressive and lethal primary malignant brain tumor in adults, characterized by extensive heterogeneity and a profoundly immunosuppressive microenvironment. Despite advances in surgery, radiotherapy, and chemotherapy, therapeutic outcomes remain poor. Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable efficacy in hematologic malignancies and is now being explored for solid tumors such as GBM. Given the expanding research landscape, a systematic understanding of global trends and hotspots in this domain is urgently needed.

Methods

We conducted a comprehensive bibliometric and visualized analysis of publications related to CAR-T cell therapy in GBM from inception to December 31, 2024, using the Web of Science Core Coll

SUBMITTER: Li J 

PROVIDER: S-EPMC12480216 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature