Identification and prognostic significance of Ki-67-related genes in triple negative breast cancer.

ABSTRACT:

Objective

This study was aimed to screen and validate key genes associated with Ki-67 expression and evaluate their prognostic significance in patients with triple-negative breast cancer (TNBC).

Methods and results

RNA sequencing data and clinical characteristics were obtained from the Fudan University Shanghai Cancer Center (FUSCC) database. A Cox regression model and bioinformatic analyses were employed to identify Ki-67-related prognostic genes. Candidate genes were further validated using the Kaplan-Meier Plotter database and patient specimens from our medical center. A total of 241 differentially expressed genes between high and low Ki-67 expression groups were initially identified through Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pat

SUBMITTER: Li W 

PROVIDER: S-EPMC12480289 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature