Tumor size in the management of preoperative radiotherapy for locally advanced rectal cancer.

ABSTRACT:

Background

To identify tumor size could be taken as a decision-making factor in the management of preoperative radiotherapy (RT) for patients with locally advanced rectal cancer (LARC).

Methods

In this study, patients diagnosed with rectal adenocarcinoma and staged at II/III from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2014 were included. Kaplan-Meier curve was conducted to investigate the overall survival (OS) between subgroups with different tumor sizes and the relationship between the tumor size and the efficacy of preoperative RT.

Results

There were 1402 patients eligible for this study, of whom 1105 (78.8%) received preoperative radiotherapy (RT + S group) and 297 (21.2%) underwent surgery alone (S group). The median OS was co

SUBMITTER: Zhong X 

PROVIDER: S-EPMC12480291 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature