Exploring drug repurposing for PAK2 inhibition: a systematic virtual screening of FDA-approved drugs against cancer.

ABSTRACT: The p21-activated kinase 2 (PAK2), a serine/threonine kinase, directly participates in the regulation of various cellular signaling pathways and plays a critical role in cell motility, survival, and proliferation. Due to its crucial role in cell signaling pathways, cytoskeletal organization, and cell survival, PAK2 has emerged as a promising drug target, especially in cancer and cardiovascular diseases. However, systematic studies examining PAK2 inhibition are still limited, and an effective inhibitor has proven quite challenging to develop. Existing drug discovery methods are labor-intensive and expensive. Therefore, new approaches like drug repurposing are required. Here, we employed a systematic, structure-based drug repurposing strategy to identify potential repurposed inhibitors of PA

SUBMITTER: Wahab S 

PROVIDER: S-EPMC12480294 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature