Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Reports of direct-acting antivirals (DAA) use for chronic hepatitis C virus (HCV) infection after successful treatment of hepatocellular carcinoma (HCC) have suggested higher rates of HCC recurrence. However, other studies have indicated no increased risk of HCC recurrence.

Methods

To estimate the comparative risk of early HCC recurrence in adults successfully treated for HCC and subsequently treated with interferon (IFN)-free DAAs versus not treated with DAAs for chronic HCV, we conducted a systematic literature review and meta-analysis following established guidelines.

Results

Forty-one cohort studies (10,563 total participants) were identified. The following mutually exclusive comparisons to DAA therapy were determined: IFN-based therapy; no DAA; and n

SUBMITTER: Lindsley K 

PROVIDER: S-EPMC12480317 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature