Local homeostasis preserves global neural dynamics compensating for structural loss during human lifespan aging.

ABSTRACT: Aging brain undergoes a structural decline over lifespan accompanied by changes in neurotransmitter levels, leading to altered functional markers. Past studies have reported human resting state brain display a remarkable preservation of coordination among neural assemblies stemming from an underlying neurocomputational principles along aging trajectories, however, the true nature of which remains unknown. Here, we identify the computational mechanisms with which neurotransmitters, such as altered GABA and glutamate concentrations, can preserve functional integration across lifespan aging, despite structural decline. We employ multiscale, biophysically grounded modeling, constrained by the empirically derived anatomical connectome of the human brain, where the neurotransmitter concentration

SUBMITTER: Saha S 

PROVIDER: S-EPMC12480457 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature