Dexmedetomidine regulates the SIRT3-mediated JAK2/STAT3 signaling pathway to protect against sepsis-induced intestinal injury.

ABSTRACT: Sepsis is a clinical syndrome triggered by a dysregulated host response to pathogens that leads to multiple organ dysfunction. Intestinal barrier function plays a pivotal role in the pathogenesis and progression of sepsis. The present study investigated the potential therapeutic role of dexmedetomidine (DEX) in sepsis-induced intestinal injury and explored the underlying molecular mechanisms. This study included a cohort of 57 patients with sepsis treated with or without DEX. A mouse model of cecal ligation and puncture (CLP)-induced sepsis combined with lipopolysaccharide (LPS)-challenged intestinal epithelial cells was used to evaluate the therapeutic potential of DEX against sepsis-associated intestinal injury. Serum levels of inflammatory markers (TNF-α, IL-6) and the intestinal injury

SUBMITTER: Gu H 

PROVIDER: S-EPMC12480493 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature