Leishmania amazonensis impairs phagosome acidification in B-1 phagocytes as an unrecognized parasite infection and proliferation mechanism.

ABSTRACT: Leishmaniasis is a neglected disease affecting people from tropical and subtropical areas. It is caused by protozoan parasites called Leishmania and transmitted by sandflies during blood meal. In phagocytic cells such as macrophages, L. amazonensis modulates endosomal/lysosomal trafficking pathways to form large parasitophorous vacuoles (PV) enabling parasite survival and proliferation. In this work, we report that upon invasion in a subset of phagocytic B (termed B-1P) cells, L. amazonensis survives and proliferates at high rates inside abnormally large and non-acid PV. Mechanistically, we show that the biogenesis of enlarged non-acidic lysosomal compartment is not directly linked to the regulation of the LYST/Beige gene that controls the expansion of Leishmania-PV in macrophages, but to

SUBMITTER: Ferreira NS 

PROVIDER: S-EPMC12480494 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature