A randomized, controlled, double-blinded trial on the effects of acellular dermal matrices on the functional assessment and qualitative satisfaction of split-thickness skin grafts.

ABSTRACT: Acellular dermal matrix (ADM) has been widely used in skin grafting to provide a dermal layer for facilitating graft take and mature scarring. This randomized controlled, double-blinded superiority study aimed to quantitatively assess the effects of this technique on the resulting graft sites via functional measurements including elasticity, humidification, transepidermal water loss (TEWL), pigmentation, and erythema at 6 months after surgery. A survey was performed to evaluate the satisfaction levels of both patients and surgeons. We considered patients with full-thickness skin defects for whom split-thickness skin grafts (STSGs) were used. By random assignment, they were allocated to the ADM group or the STSG-only group. The ADM group received STSG with a ADM layer on the defect, whereas

SUBMITTER: Lee CR 

PROVIDER: S-EPMC12480496 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature