Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.

ABSTRACT: Gut microbiota influence the severity of pneumonia by producing metabolites that enhance systemic and pulmonary immune responses. Preclinical studies suggested that gut microbiota-derived indoles have protective effects against numerous diseases, including influenza and abdominal infections. However, the precise role of tryptophan metabolites during pneumonia is unknown. Here, we perform translational analyses in a large general-population cohort (n = 13,464), critically ill patients with severe community-acquired pneumonia (CAP; n = 158; NCT01905033), a randomized human intervention trial on antibiotic-mediated microbiota modulation (NCT03051698), and mice to investigate the effects of tryptophan metabolites, specifically indole-3-acetic acid (IAA), on pneumonia. In the population-based c

SUBMITTER: Kullberg RFJ 

PROVIDER: S-EPMC12480536 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature