Link between the ESR2 (rs3020449) polymorphism and breast cancer risk in Bangladeshi women.

ABSTRACT: Worldwide, breast carcinoma represents the single most widespread disease among women as well as the second most prevalent malignancy overall. This condition is heterogeneous, comprising multiple distinguished subgroups characterized by unique gene transcription variations and varying mortality rates. Multiple diverse studies suggest that estrogen receptor gene polymorphisms might impact BC susceptibility and formation, which may alter receptor function, tumor expansion, and sensitivity to hormonal therapies. These genes regulate estrogen signaling pathways, affecting breast cancer (BC) formation. The linkage of various polymorphisms of ESR2 gene on BC development is not comprehended. Hence, our objective was to scrutinize the correlation among the ESR2 (rs3020449) polymorphism and BC risk

SUBMITTER: Shayla TA 

PROVIDER: S-EPMC12480556 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature