The shared genetic architecture between schizophrenia and common peripheral organ imaging phenotypes.

ABSTRACT: Schizophrenia (SCZ) is a complex neuropsychiatric disorder that profoundly disrupts daily life. Beyond its well-documented effects on the brain, SCZ is also associated with peripheral organ dysfunction, yet the underlying shared genetic mechanisms remain unclear. In this study, leveraging large-scale genome-wide association study (GWAS) data, we investigated the genetic architecture shared between SCZ and 47 common imaging phenotypes spanning three major peripheral organs: 28 cardiac magnetic resonance (CMR) phenotypes, eight skeletal dual-energy X-ray absorptiometry (DXA) phenotypes, and 11 abdominal magnetic resonance imaging (MRI) phenotypes. We identified seven significant causal associations between SCZ and peripheral organ imaging phenotypes, alongside 99 unique loci through local ge

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12480580 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature