Flow cytometry-based evaluation of CD4/CD25 and IL-17 expression in sepsis of cancer surgical patients.

ABSTRACT:

Introduction and objectives

Sepsis is a critical, life-threatening condition marked by organ dysfunction. Patients undergoing surgery for cancer are especially susceptible, facing a significantly increased risk compared to the general population. Prompt diagnosis is essential for optimal treatment outcomes. This study investigates the expression levels of IL-17 and CD4/CD25 in postoperative surgical oncology patients diagnosed with sepsis and examines their association with various clinicopathological parameters, including mortality.

Methods

Peripheral blood samples were collected 48 h following admission to the surgical ICU. Flow cytometry was employed to measure the expression of IL-17 and CD4/CD25 in both septic patients and non-septic controls.

Results

The study i

SUBMITTER: Abdelhafiz AS 

PROVIDER: S-EPMC12480818 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature