The histone methyltransferase SETD2 regulates adult brain structure, connectivity and neurogenesis.

ABSTRACT: Epigenetic mechanisms are crucial for neocortical development. Recent work has highlighted that ablation of Setd2, which encodes a SET domain lysine methyltransferase, from the mouse dorsal telencephalon results in deficits in reciprocal cortico-thalamic connectivity. However, analysis of broader cortical phenotypes in this model has yet to be performed. Here, we addressed this, revealing that dorsal telencephalon-specific ablation of Setd2 results in decreased structural volumes across the entire adult brain, particularly within the hippocampus. Moreover, while homozygous Setd2-deficient brains exhibited apparently normal axonal integrity within the corpus callosum, axonal connections arising from the hippocampus were significantly impacted. Furthermore, whole brain structural connectivit

SUBMITTER: Atterton C 

PROVIDER: S-EPMC12480832 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature