The pathogen effector BcSSP2 suppresses the NPC phase separation to facilitate Botrytis cinerea infection.

ABSTRACT: Biomolecular phase separation-mediated immunity was recently uncovered as an important strategy of plants and animals for their survival in the challenging environment. Effectors are powerful weapons evolved by pathogens to overcome host defense response for effective infection. However, plant pathogen effectors were rarely identified to suppress the phase separation-mediated host defense response. Here, we report a pathogen effector that disrupts phase separation process in host cells to suppress host defense response and facilitate pathogen infection. We identify a host-internalized effector protein BcSSP2 from a disastrous pathogen Botrytis cinerea targets the central barrier of plant nuclear pore complex (NPC). BcSSP2 disrupts the phase separation of NUP62 and attenuates phase separati

SUBMITTER: Wang J 

PROVIDER: S-EPMC12480848 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature