BLVRA promotes glioblastoma progression by regulating fatty acid metabolism.

ABSTRACT: Fatty acid metabolism is critically involved in glioblastoma (GBM) pathogenesis; however, its regulatory mechanisms remain incompletely understood. In this study, we identified biliverdin reductase A (BLVRA) as a novel metabolic driver and prognostic biomarker in GBM by integrating bulk and single-cell RNA sequencing with in vitro functional validation. Using ten machine learning algorithms, we developed a fatty acid metabolism-related gene prognostic index (FAMRGPI), which demonstrated strong prognostic value and highlighted the importance of metabolic reprogramming and immune modulation in GBM. Among FAMRGPI components, BLVRA emerged as an independent prognostic factor, with elevated expression associated with poor clinical outcomes. Single-cell transcriptomic analysis revealed that BLVR

SUBMITTER: Li L 

PROVIDER: S-EPMC12480882 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature