Molecular characterization of hereditary breast and ovarian cancer patients from a public precision medicine service in the Southeast Brazilian population.

ABSTRACT: To address the need for specialized care in hereditary cancer, we developed a Hereditary Cancer Predisposition Assessment and Family Monitoring Program in the southeast of Brazil. The program was designed to identify suspected cases and provide molecular diagnostic testing through a structured care flow that included genetic counseling, psychological support, and clinical follow-up. This initiative targeted individuals within the public healthcare system and aimed to implement accessible precision medicine approaches for hereditary cancer syndromes. As part of this initiative, we performed systematic genetic screening using both Sanger sequencing and a next-generation sequencing panel to investigate cancer susceptibility genes in a cohort of 210 patients with suspected Hereditary Breast an

SUBMITTER: Ribeiro AAF 

PROVIDER: S-EPMC12480894 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature