Alterations in Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents.

ABSTRACT:

Background

Callous-unemotional (CU) traits during adolescence, for example, shallow affect or lack of remorse, have been shown to be a risk marker for antisocial behavior. Only a few studies have investigated structural brain alterations underlying CU traits, and findings are inconclusive. The study examines CU symptomatology and gray matter volume (GMV) associations.

Methods

Structural brain MRI data were collected from a sample of 578 adolescents (60% male) with a mean age of 14.85 years (SD = 2.30; range = 10-19 years). CU traits were indexed via the Inventory for Callous Unemotional Traits (ICU). Region-wise volumetric parameters were obtained following parcellation of the brain into 68 cortical and 14 subcortical regions per participant. A multiple linear regression was

SUBMITTER: Bashford-Largo J 

PROVIDER: S-EPMC12480921 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature