Persistent tissue regeneration and transforming growth factor-β induced fibrosis in the masseter muscle of mdx^5Cv mice.

ABSTRACT: Clinical observational studies have shown that patients with Duchenne muscular dystrophy (DMD) often develop orofacial dysfunction. However, most DMD mouse model studies have focused on limb and respiratory muscles, showing an extensive wave of muscle necrosis-regeneration in juveniles followed by a low-intensity chronic disease in adults. In the present study, we investigated the impact of DMD on the masseter muscles in mice and observed persistence and progression of the conditions at least until 12 months of age. Masseter and limb muscles from mdx^5Cv mice aged 3, 6, and 12 months were compared with those from control mice (C57BL/6 J background), measuring levels of necrosis, regeneration, inflammation, and fibrosis. In addition, mRNA expression of markers associated with fibr

SUBMITTER: Ait-Lounis A 

PROVIDER: S-EPMC12480963 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature