A miRNA signature linked to high lipoprotein (a) and coronary calcification in familial hypercholesterolaemia.

ABSTRACT:

Background

High lipoprotein(a) [Lp(a)] levels are associated with increased coronary artery calcification (CAC) in familial hypercholesterolaemia (FH) patients. However, mechanisms linking high Lp(a) with CAC remain poorly understood. In this study, we have performed a bioinformatics and system biology analysis to identify miRNAs and their target genes involved in Lp(a)-associated atherosclerotic lesion and coronary calcification in FH patients.

Methods

Patients with a genetic diagnosis of FH (n = 24) from the SAFEHEART were included in the study. Plasma miRNA signature was obtained using Affymetrix miRNA microarrays from patients with FH grouped using an Lp(a) cut-off of (>50 mg/dL) and presence or absence of coronary artery calcification [CCS(+) or CCS(-)]. In si

SUBMITTER: Escate R 

PROVIDER: S-EPMC12481025 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature