Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques.

ABSTRACT: Modern antiretroviral therapy (ART) regimens have revolutionized the management of human immunodeficiency virus (HIV) and transformed it from a life-threatening disease to a manageable chronic condition. Despite the durable viral suppression associated with ART adherence, people with HIV (PWH) continue to experience chronic immune activation and inflammation, which has been linked with increased risk of developing non-acquired immunodeficiency syndrome (AIDS) comorbidities, including cardiovascular disease, liver disease, or neurocognitive disorders. Importantly, the mechanisms underlying establishment and maintenance of immune activation in ART-treated PWH remain incompletely defined. Here, we used a nonhuman primate model to evaluate associations between markers of systemic immune activa

SUBMITTER: Fell SL 

PROVIDER: S-EPMC12481039 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature