Idiopathic inflammatory myopathies lack neutralising autoantibodies to type- I, II and III interferons.

ABSTRACT:

Objective

To determine whether autoantibodies against interferons are present and play a role in disease modulation in idiopathic inflammatory myopathies (IIMs).

Methods

We screened for autoantibodies against a large number of interferons (IFNs) and other cytokines in a cross-sectional observational cohort of Swedish patients with anti-synthetase syndrome (n=51) and dermatomyositis (n=48), matched together with blood donors (n=100) from general population, using both planar and suspension-based multiplex assays. A single patient with autoimmune polyendocrine syndrome, type-1 (APS-1), known to harbour autoantibodies that neutralise type-I interferons, was included as a reference biological positive. The functional ability of autoantibodies to neutralise type-I interferons was

SUBMITTER: Behere A 

PROVIDER: S-EPMC12481268 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature