Causal mediation analysis of a randomised controlled trial in China: evaluating whether the pay-it-forward strategy increases HPV vaccine uptake by reducing vaccine delay intention and increasing vaccine confidence.

ABSTRACT:

Objective

To explore whether vaccine confidence and vaccine delay intention mediated the effect of the pay-it-forward intervention on human papillomavirus (HPV) vaccine uptake.

Design

This secondary mediation analysis of a two-arm randomised controlled trial was conducted among female adolescents aged 15-18 years in Chengdu, China, from July 2022 to June 2023.

Setting

This study was conducted in four residential areas representing diverse economic backgrounds in Chengdu.

Participants

A total of 321 parents of girls aged 15-18 years who had not received the HPV vaccine participated in the study.

Intervention

Participants were randomly allocated into two arms. Pay-it-forward participants received a community-contributed subsidy (47.7 USD) to support the HP

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12481287 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature