Frequency and severity of COPD exacerbations and future risk of exacerbations and mortality: an observational cohort study in Canada.

ABSTRACT:

Objectives

To estimate the risk of subsequent exacerbations, in relation to history of exacerbations, in a cohort of older chronic obstructive pulmonary disease (COPD) patients in Canada.

Methods

Using provincial claims data from Ontario, Canada, patients with COPD aged≥65 years (identified between 2004 and 2018; followed up to 2020) were categorised into one of four mutually exclusive groups: no exacerbation; only one moderate; only one severe; or two or more exacerbations of any severity (moderate or severe) during the baseline period. The index date was the first documentation of a COPD diagnosis code; the subsequent 12 months served as the baseline period. Adjusted risks of subsequent exacerbations (any severity and severe exacerbation, separately) by the end of postbase

SUBMITTER: Duong ML 

PROVIDER: S-EPMC12481290 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature