Impact of LISA failure on 2-year neurodevelopmental outcomes in preterm infants: a retrospective cohort study.

ABSTRACT:

Background

Less invasive surfactant administration (LISA) reduces the need for mechanical ventilation in preterm infants with respiratory distress syndrome. However, some LISA-treated infants require intubation within 72 hours due to continuous positive airway pressure (CPAP) failure (LISA failure, LISA-F). The long-term neurodevelopmental impact of LISA-F remains unclear.

Objective

To compare 2-year neurodevelopmental outcome in preterm infants with successful LISA (LISA-S) versus LISA-F and primary intubation for surfactant (PI).

Methods

Retrospective cohort study (2015-2023) including infants from 24 to 29 weeks gestational age (GA) with surfactant administration; categorised into three groups: LISA-S (n = 235), LISA-F (n = 117) and PI for surfactant (n = 102). Neu

SUBMITTER: Swinkels FPM 

PROVIDER: S-EPMC12481382 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature