Intra-articular sustained-release colchicine is efficacious in an inflammatory arthritis rat model.

ABSTRACT:

Objectives

Gout is a common disease causing excruciatingly painful and disabling flares. Although currently approved treatments for gout flares are generally effective, their use is restricted in many patients who present contraindications. There is a clear unmet need for treatments, with a rapid onset of action and a good safety profile. This study evaluates the efficacy of intra-articular (IA) colchicine (COL)-loaded microspheres enabling sustained-release colchicine (SR-COL), and of a combination of SR-COL with an anaesthetic (Ropivacaine HCl, ROPI) (PKM-01) in a rat model of acute inflammatory arthritis.

Methods

PKM-01 combines ROPI with SR-COL, prepared using a polylactic-co-glycolic acid matrix polymer. A model of IA carrageenan (CAR)-induced arthritis in knees or ankl

SUBMITTER: Grassot J 

PROVIDER: S-EPMC12481383 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature