Comparative analysis of global practices in the management of colchicine-resistant familial Mediterranean fever: a CliPS network analysis.

ABSTRACT:

Background

Although colchicine is the mainstay of familial Mediterranean fever (FMF) treatment, 5-10% of patients are considered to have colchicine resistance (CR). However, there is no globally agreed CR definition or indications for biological disease-modifying anti-rheumatic drugs (bDMARDs).

Methods

A survey on 'Biologics in Monogenic Autoinflammatory Diseases', part of the 'Clinical Practice Strategies' (CLiPS) initiative, was conducted by a JIR cohort-initiated eCOST network among expert participants worldwide. Our primary aim was to provide a flowchart reflecting the different CR definitions and present data regarding bDMARD indications. The secondary aim was to determine how specific biases influence clinical approaches. We analysed the CliPS according to the experien

SUBMITTER: Haslak F 

PROVIDER: S-EPMC12481408 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature