A Randomized, Double-Blind, Placebo Controlled, Crossover Trial of incobotulinumtoxinA Treatment for Upper Limb Tremor.

ABSTRACT:

Background

Proximal upper limb tremor is a common, functionally disabling condition. Medical therapy is often ineffective. IncobotulinumtoxinA can significantly improve tremor with minimal adverse effects.

Objectives

We aimed to compare clinical, functional, and quality of life measures in patients with proximal upper limb tremor following incobotulinumtoxinA treatment.

Methods

We undertook a double-blind, randomized two-sequence, two-period, two-treatment, placebo-controlled cross-over trial. Twenty adult patients with proximal upper limb tremor were recruited from a tertiary movement disorders clinic. Patients were randomized 1:1 to alternate electromyographically guided intramuscular injections of either incobotulinumtoxinA or saline to the dominant upper limb usin

SUBMITTER: Nagaratnam SA 

PROVIDER: S-EPMC12481436 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature