Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.

ABSTRACT: Klebsiella pneumoniae is a Gram-negative opportunistic bacterial pathogen and a common cause of urinary tract infections (UTIs). In Bangladesh, a rapid increase in antibiotic resistance in K. pneumoniae, with a concerning prevalence of pan-drug resistant (PDR) isolates, is severely limiting treatment options and posing a threat to public health. K. pneumoniae isolate KPNW was found in a clinical urine sample of a UTI patient from Dhaka, Bangladesh. In the disc diffusion test, KPNW showed resistance to 28 antibiotics across multiple classes, including carbapenems and colistin. Whole genome sequencing, assembly, and annotation yielded a 5.48 Mb genome encoding 5554 genes. Four plasmid replicons-lncFIB(K), lncFII(K), lncN2, and lncX3-were identified, all having known associations with antimic

SUBMITTER: Murad MW 

PROVIDER: S-EPMC12481437 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature