The analysis of the gut microbiome during liver disease progression led to the identification of biomarkers for related mild cognitive impairment.

ABSTRACT:

Introduction

Although it is well established that liver disease is associated with alterations in the gut microbiome (GM), the mechanisms linking these microbial changes to the progression of liver disease-and more critically, to its related cognitive impairment-remain poorly understood. Therefore, to define biomarkers for the early and advanced phases of these conditions, it is necessary to gain insight into changes in the GM throughout the evolution of the disease, particularly regarding the early onset of cognitive decline.

Methods

The GM taxonomy and function profiles were defined, data were collected for dietary intake, fecal short-chain fatty acids (SCFA), cognitive status, quality of life and biochemical and immunological blood parameters of patients belonging to diff

SUBMITTER: Giner-Perez L 

PROVIDER: S-EPMC12481516 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature