Is <i>Candida albicans</i> a promoting factor, rather than an inducing factor for oral cancer?

ABSTRACT:

Background

Candida albicans (C. albicans) is closely associated with cancer. Whether C. albicanscan directly induce the occurrence of oral cancer remains undetermined.

Objective

This study aimed to explore the carcinogenic potential of C. albicans in oral cancer.

Methods

Transcriptome sequencing (mRNAseq) and whole exome sequencing (WES) were performed to reveal the effects of long-term C. albicans stimulation on oral mucosa in mouse models. 4-nitroquinoline-1-oxide (4NQO), a mutagenic substance that mimics tobacco, was used to examine the combined role of tobacco smoking and C. albicans in oral carcinogenesis. Additionally, the somatic mutation landscape of chronic hyperplastic candidiasis (CHC)-a variant of oral candidiasis

SUBMITTER: Wang X 

PROVIDER: S-EPMC12481529 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature