Halogenation-Guided Chemical Screening Uncovers Cyanobacterin Analogues from the Cyanobacterium <i>Tolypothrix</i> sp. PCC9009.

ABSTRACT: Halogenated specialized metabolites show high chemical diversity and exhibit a range of biological activities. A targeted screening of a cyanobacteria extract library for halogenated specialized metabolites using HPLC-HRMS combined with MassQL and Haloseeker indicated that several of the extracts contained halogenated compounds, among them an extract of Tolypothrix sp. PCC9009. This freshwater cyanobacterium has been known since the early 1980s for producing the chlorinated specialized metabolite cyanobacterin, containing a γ-lactone core structure with a hydroxy group that is essential for its herbicidal activity against cyanobacteria and green algae. Mass-spectrometry-based molecular networking was employed to explore the chemical space of natural cyanobacterin analogues. This ana

SUBMITTER: Schanbacher F 

PROVIDER: S-EPMC12481558 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature