Structurally Engineered All-Polymeric Microneedle Sensor for Highly Sensitive and Real-Time Monitoring of Glucose in Interstitial Fluids.

ABSTRACT: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia with multiple clinical manifestations and complications, such as cardiovascular disease, kidney dysfunction, retinal impairment, and peripheral neuropathy. Continuous and minimally invasive glucose monitoring is essential for effective DM management. Microneedles (MNs)-based sensing platforms offer a promising solution; however, conventional polymeric MNs suffer from limited electrochemical sensitivity due to their insufficient electroactive surface area and inefficient loading of catalytic and enzymatic components. Herein, we present a fully polymeric, high-sensitive glucose sensor based on structurally engineered mushroom-shaped MNs. The MNs were fabricated from a biocompatible composite of t

SUBMITTER: Kim JH 

PROVIDER: S-EPMC12481562 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature